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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

DNA Methyltransferase 1 Monoclonal Antibody (Clone 60B1220.1)

Cayman Chemical Item Number 13479

DNMT1

DNA Methyltransferase 1 Monoclonal Antibody (Clone 60B1220.1)

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Description

Antigen: synthetic peptide corresponding to amino acids 637-650 (EKDDREDKENAFKR) of human DNMT1 · Clone designation: 60B1220.1 · Host: mouse · Isotype: IgG1κ · Application(s): WB, IHC (paraffin-embedded sections), ChIP, and IP · Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting, and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, three families of mammalian DNA methyltransferase genes have been identified which include DNMT1, DNMT2, and DNMT3. DNMT1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. DNMT2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. The DNMT3 family members, DNMT3a and DNMT3b, are strongly expressed in ES cells but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue. DNMT1 co-purifies with the retinoblastoma (Rb) tumour suppressor gene product, E2F1, and HDAC1. DNMT1 also cooperates with Rb to repress transcription from promoters containing E2F-binding sites suggesting a link between DNA methylation, histone deacetylase, and sequence-specific DNA binding activity, as well as a growth-regulatory pathway that is disrupted in nearly all cancer cells.
Synonyms
  • DNMT1
Formulation 100 µg IgG in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Specificity
Human DNMT1 +
Mouse DNMT1 +
Zebrafish DNMT1 +
Size Price Quantity Subtotal
1 ea $250.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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