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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

DNA Methyltransferase 2 Polyclonal Antibody

Cayman Chemical Item Number 13480

DNMT2

DNA Methyltransferase 2 Polyclonal Antibody

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Description

Antigen: synthetic peptides corresponding to amino acids 39-54 (ANEVYKHNFPHTHLLS) and 361-376 (PEKTTVKQRYRLLGNS) of mouse DNMT2 · Host: rabbit · Application(s): WB · Methylation of DNA at cytosine residues plays an important role in the regulation of gene expression, genomic imprinting, and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, three families of mammalian DNA methyltransferase genes have been identified which include DNMT1, DNMT2, and DNMT3. DNMT1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. DNMT2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. DNMT2 contains all the sequence motifs diagnostic of DNA (cytosine-5)-methyltransferases but appears to lack the large N-terminal regulatory domain common to other eukaryotic methyltransferases.
Synonyms
  • DNMT2
Formulation 100 µg of Protein G-purified IgG in 200 µl PBS containing 0.02% sodium azide
Stability 6 months
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Specificity
Human DNMT2 +
Mouse DNMT2 +
Size Price Quantity Subtotal
1 ea $213.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-11. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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