ARAP2 Polyclonal Antibody
Cayman Chemical Item Number 13495
Centaurin-δ-1
ARAP2 Polyclonal Antibody
Description
Antigen:
synthetic peptide from human ARAP2 within the region of amino acids 1,670-1,720
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Host:
rabbit
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Application(s):
WB and IHC
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ARAP2, also known as centaurin-d-1, is a protein with ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. A phosphatidylinositol-3,4,5-trisphosphate (PtdIns-(3,4,5)-P3)-dependent GTPase-activating protein, ARAP2, binds to RhoA-GTP, but lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. It modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Usually ARAP2 is activated by PtdIns-(3,4,5)-P3 binding and can be activated by PtdIns-(3,4)-P2 binding, although with lower efficiency. ARAP2 associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. It is usually detected in brain, thymus, lymph node, thyroid, spinal cord, trachea, heart, skeletal muscle, spleen, kidney, liver, placenta, lung, and peripheral blood leukocytes.
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| Formulation |
100 µg of protein A-purified IgG in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide |
| Stability |
1 year |
| Storage |
-20°C |
| Shipping |
Wet ice
in continental US; may vary elsewhere
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| Specificity |
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Pricing updated 2012-05-26.
Prices are subject to change without notice.
To ask for assistance with one of our products please contact a Technical Support Scientist.
Warning This product is not for human or veterinary use.
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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.
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