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Holiday Notification: Cayman Chemical will be closed Monday, May 28, 2012, in observance of the Memorial Day holiday. More…
Please feel free to continue placing orders via our website or via fax at 734-971-3640. You may send an email to customer service at custserv@caymanchem.com , or to technical support at techserv@caymanchem.com which we will respond to the next business day. Cayman will resume regular business hours and shipping schedules on Tuesday, May 29, 2012. Thank you for your patience and understanding.

ARRB2 Polyclonal Antibody

Cayman Chemical Item Number 13498

β-Arrestin-2

ARRB2 Polyclonal Antibody

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Description

Antigen: synthetic peptide from human ARRB2 within the region of amino acids 15-50 · Host: rabbit · Application(s): WB and IHC · β-Arrestin-2 (ARRB2) is an adaptor protein belonging to the arrestin family with an N-arrestin domain and a C-arrestin domain. ARRB2 is a regulatory protein involved in heterotrimeric G protein-coupled receptor desensitization and is known to regulate β-adrenergic receptor A function, thus enhancing β2AR receptor mediated nuclear translocation of ERK. It binds to phosphorylated β-adrenergic receptors, thereby causing a significant impairment of their capacity to activate Gs proteins. Along with AIP4, ARRB2 acts as an endosomal sorting molecule that mediates CXCR4 entry into a degradative pathway. It may also be involved in hormone-specific desensitization of TSH receptors. ARRB2 is a Ca2+ binding protein of the retinal outer segments and binds to P-rhodopsin and is also involved in synaptic transmission in photoreceptor cells. It is widely expressed in most of the tissues, especially neuronal tissues and spleen.
Synonyms
  • β-Arrestin-2
Formulation 100 µg of peptide affinity-purified IgG in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Specificity
Ovine ARRB2 +
Canine ARRB2 +
Equine ARRB2 +
Monkey ARRB2 +
Mouse ARRB2 +
Rat ARRB2 +
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Size Price Quantity Subtotal
1 ea $234.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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