13498 ARRB2 Peptide Affinity-purified Polyclonal Antibody
β-Arrestin-2
ARRB2 Peptide Affinity-purified Polyclonal Antibody Workbook Links
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Antigen:
synthetic peptide from human ARRB2 within the region of amino acids 15-50
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Host:
rabbit
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Application(s):
WB and IHC
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β-Arrestin-2 (ARRB2) is an adaptor protein belonging to the arrestin family with an N-arrestin domain and a C-arrestin domain. ARRB2 is a regulatory protein involved in heterotrimeric G protein-coupled receptor desensitization and is known to regulate β-adrenergic receptor A function, thus enhancing β2AR receptor mediated nuclear translocation of ERK. It binds to phosphorylated β-adrenergic receptors, thereby causing a significant impairment of their capacity to activate Gs proteins. Along with AIP4, ARRB2 acts as an endosomal sorting molecule that mediates CXCR4 entry into a degradative pathway. It may also be involved in hormone-specific desensitization of TSH receptors. ARRB2 is a Ca2+ binding protein of the retinal outer segments and binds to P-rhodopsin and is also involved in synaptic transmission in photoreceptor cells. It is widely expressed in most of the tissues, especially neuronal tissues and spleen.
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Purchase 13498 ARRB2 Peptide Affinity-purified Polyclonal Antibody
Pricing is for North America only. Other customers should contact a distributor in their region.
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Warning This product is not for human or veterinary use.
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Pricing updated 2010-03-19.
Prices are subject to change without notice.
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