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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

ARRB2 Polyclonal Antibody

Cayman Chemical Item Number 13498

β-Arrestin-2

ARRB2 Polyclonal Antibody

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Description

Antigen: synthetic peptide from human ARRB2 within the region of amino acids 15-50 · Host: rabbit · Application(s): WB and IHC · β-Arrestin-2 (ARRB2) is an adaptor protein belonging to the arrestin family with an N-arrestin domain and a C-arrestin domain. ARRB2 is a regulatory protein involved in heterotrimeric G protein-coupled receptor desensitization and is known to regulate β-adrenergic receptor A function, thus enhancing β2AR receptor mediated nuclear translocation of ERK. It binds to phosphorylated β-adrenergic receptors, thereby causing a significant impairment of their capacity to activate Gs proteins. Along with AIP4, ARRB2 acts as an endosomal sorting molecule that mediates CXCR4 entry into a degradative pathway. It may also be involved in hormone-specific desensitization of TSH receptors. ARRB2 is a Ca2+ binding protein of the retinal outer segments and binds to P-rhodopsin and is also involved in synaptic transmission in photoreceptor cells. It is widely expressed in most of the tissues, especially neuronal tissues and spleen.
Synonyms
  • β-Arrestin-2
Formulation 100 µg of peptide affinity-purified IgG in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Specificity
Ovine ARRB2 +
Canine ARRB2 +
Equine ARRB2 +
Monkey ARRB2 +
Mouse ARRB2 +
Rat ARRB2 +
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Size Price Quantity Subtotal
1 ea $234.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-10. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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