HDAC11 Polyclonal Antibody

Cayman Chemical Item Number 13504

Histone Deacetylase 11

Description

Antigen: synthetic peptide from human HDAC11 amino acids (AHQGNGHERDFMDDKRVY) · Host: rabbit · Application(s): WB · Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the ε-amino groups of lysines located near the amino termini of core histone proteins.¹ Eleven members of HDAC family have been identified in the past several years.^2,3 These HDAC family members are divided into two classes, I and II.The newest memeber of this family, HDAC11, has been cloned by Gao et al.⁴ HDAC11 transcripts were limited to kidney, heart, brain, skeletal muscle, and testis. These results suggested that each member of the HDAC family exhibits a different, individual substrate specificity and function in vivo.

1 Gao, L., Cueto, M.A., Asselbergs, F., et al. Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family. J Biol Chem 277(28) 25748-25755 (2002).

2 Meinke, P.T., and Liberator, P. Histone deacetylase: A target for antiproliferative and antiprotozoal agents. Curr Med Chem 8(2) 211-235 (2001).

3 Nakayama, T., and Takami, Y. Participation of histones and histone-modifying enzymes in cell functions through alterations in chromatin structure. J Biochem 129 491-499 (2001).

4 Cress, W.D., and Seto, E.J. Histone deacetylases, transcriptional control, and cancer. J Cell Physiol 184 1-16 (2000).

Synonyms

Histone Deacetylase 11

Formulation

100 μg of protein G-purified IgG in 200 μl PBS containing 0.02% gelatin and 0.05 sodium azide

Stability

1 year

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

Specificity

Human HDAC	+
Mouse HDAC11	+
Rat HDAC11	+

Background Reading

Nakayama, T., and Takami, Y. Participation of histones and histone-modifying enzymes in cell functions through alterations in chromatin structure. J Biochem 129 491-499 (2001).

Meinke, P.T., and Liberator, P. Histone deacetylase: A target for antiproliferative and antiprotozoal agents. Curr Med Chem 8(2) 211-235 (2001).

Gao, L., Cueto, M.A., Asselbergs, F., et al. Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family. J Biol Chem 277(28) 25748-25755 (2002).

Cress, W.D., and Seto, E.J. Histone deacetylases, transcriptional control, and cancer. J Cell Physiol 184 1-16 (2000).

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1 ea

$234.00

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