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Celastramycin A Exclusive

Cayman Chemical Item Number 13519

(CAS 491600-94-3)

Celastramycin A (CAS 491600-94-3)

See more	Inhibitors (546) Inflammation (396)

Description

Celastramycin A is a bioactive compound isolated from endophytic bacteria living in plants of the Celastraceae family.¹ This benzoyl pyrrole inhibits the growth of bacteria and mycobacteria, with a minimal inhibitory concentration as low as 0.05 μg/ml.¹ Celastramycin A also suppresses the production of interleukin-8 in human umbilical vein endothelial cells as stimulated by tumor necrosis factor-α (IC₅₀ = 0.01 μg/ml).²

1 Pullen, C., Schmitz, P., Meurer, K., et al. New and bioactive compounds from Streptomyces strains residing in the wood of Celastraceae. Planta 216 162-167 (2002).

2 Kikuchi, H., Sekiya, M., Katou, Y., et al. Revised structure and synthesis of Celastramycin A, a potent innate immune suppressor. Org Lett 11(8) 1693-1695 (2009).

Formal Name	(3-chloro-5-hexyl-2,6-dihydroxyphenyl)(4,5-dichloro-1H-pyrrol-3-yl)-methanone
CAS Number	491600-94-3
Molecular Formula	C₁₇H₁₈Cl₃NO₃
Formula Weight	390.7
Formulation	A crystalline solid
Purity	≥97%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard ClC1=CC(CCCCCC)=C(O)C(C(C2=CC(Cl)=C(Cl)N2)=O)=C1O

Background Reading

Pullen, C., Schmitz, P., Meurer, K., et al. New and bioactive compounds from Streptomyces strains residing in the wood of Celastraceae. Planta 216 162-167 (2002).

Kikuchi, H., Sekiya, M., Katou, Y., et al. Revised structure and synthesis of Celastramycin A, a potent innate immune suppressor. Org Lett 11(8) 1693-1695 (2009).

Size	Price	Quantity	Subtotal
1 mg	$101.00		$0.00
5 mg	$455.00		$0.00
10 mg	$808.00		$0.00
25 mg	$1,768.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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