13519  Celastramycin A

(CAS 491600-94-3)

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Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Celastramycin A is a bioactive compound isolated from endophytic bacteria living in plants of the Celastraceae family.1 This benzoyl pyrrole inhibits the growth of bacteria and mycobacteria, with a minimal inhibitory concentration as low as 0.05 μg/ml.1 Celastramycin A also suppresses the production of interleukin-8 in human umbilical vein endothelial cells as stimulated by tumor necrosis factor-α (IC50 = 0.01 μg/ml).2
1  Pullen, C., Schmitz, P., Meurer, K., et al. New and bioactive compounds from Streptomyces strains residing in the wood of Celastraceae. Planta 216 162-167 (2002).
2  Kikuchi, H., Sekiya, M., Katou, Y., et al. Revised structure and synthesis of Celastramycin A, a potent innate immune suppressor. Organic Lett 11(8) 1693-1695 (2009).


Purchase 13519 Celastramycin A

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Warning This product is not for human or veterinary use.

Pricing updated 2010-03-19.
Prices are subject to change without notice.

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Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.

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