Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Celastramycin A Exclusive

Cayman Chemical Item Number 13519

(CAS 491600-94-3)

Celastramycin A (CAS 491600-94-3)

See more	Inhibitors (493) Inflammation (383)

Description

Celastramycin A is a bioactive compound isolated from endophytic bacteria living in plants of the Celastraceae family.¹ This benzoyl pyrrole inhibits the growth of bacteria and mycobacteria, with a minimal inhibitory concentration as low as 0.05 μg/ml.¹ Celastramycin A also suppresses the production of interleukin-8 in human umbilical vein endothelial cells as stimulated by tumor necrosis factor-α (IC₅₀ = 0.01 μg/ml).²

1 Pullen, C., Schmitz, P., Meurer, K., et al. New and bioactive compounds from Streptomyces strains residing in the wood of Celastraceae. Planta 216 162-167 (2002).

2 Kikuchi, H., Sekiya, M., Katou, Y., et al. Revised structure and synthesis of Celastramycin A, a potent innate immune suppressor. Org Lett 11(8) 1693-1695 (2009).

Formal Name	(3-chloro-5-hexyl-2,6-dihydroxyphenyl)(4,5-dichloro-1H-pyrrol-3-yl)-methanone
CAS Number	491600-94-3
Molecular Formula	C₁₇H₁₈Cl₃NO₃
Formula Weight	390.7
Formulation	A crystalline solid
Purity	≥97%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard ClC1=CC(CCCCCC)=C(O)C(C(C2=CC(Cl)=C(Cl)N2)=O)=C1O

Background Reading

Pullen, C., Schmitz, P., Meurer, K., et al. New and bioactive compounds from Streptomyces strains residing in the wood of Celastraceae. Planta 216 162-167 (2002).

Kikuchi, H., Sekiya, M., Katou, Y., et al. Revised structure and synthesis of Celastramycin A, a potent innate immune suppressor. Org Lett 11(8) 1693-1695 (2009).

Size	Price	Quantity	Subtotal
1 mg	$101.00		$0.00
5 mg	$455.00		$0.00
10 mg	$808.00		$0.00
25 mg	$1,768.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Thiocarlide

Downloads

	Download Product Insert 113 Kb PDF
	Download Material Safety Data Sheet (MSDS) 15 Kb PDF
	Printer-friendly version of this page small PDF (usually less than 100 Kb)
	• US Letter paper 8½″ × 11″
	• A4 paper 21cm × 29.7cm
	Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs	Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases	Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule	Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640