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Oxalomalic Acid (sodium salt)

Cayman Chemical Item Number 13521

(CAS 89304-26-7)

Oxalomalic Acid (sodium salt) (CAS 89304-26-7)

See more	Inhibitors (493) Oxidative Injury (258)

Description

Aconitase catalyzes the stereospecific isomerization of citrate to isocitrate in the first step of the citric acid cycle. It acts as an iron regulatory protein (IRP), controlling the translation of proteins involved in iron metabolism when iron is scarce and resumes aconitase activity when iron is abundant. Aconitase is now recognized as a regulator of iron-induced glutamate production.¹ Oxalomalic acid, formed by the condensation of oxaloacetate with glyoxylate in vivo, inhibits both aconitase and NADP-dependent isocitrate dehydrogenase in the conversion of citrate to isocitrate at concentrations as low as 1 mM.² At 5 mM, oxalomalic acid inhibition of aconitase leads to a decrease in the binding activity of IRP1 and a decrease in glutamate secretion in cultured lens epithelial cells, retinal pigment epithelial cells, and neurons.^3,4

1 Gerber, D.E. EGFR inhibition in the treatment of non-small cell lung cancer. Drug Dev Res 69(6) 359-372 (2008).

2 Ruffo, A., Testa, E., Adinolfi, A., et al. Control of the citric acid cycle by glyoxylate. Mechanism of the inhibition by oxalomalate and γ-hydroxy-α-oxoglutarate. Biochem J 103 19-23 (1967).

3 Festa, M., Colonna, A., Pietropaolo, C., et al. Oxalomalate, a competitive inhibitor of aconitase, modulates the RNA-binding activity of iron-regulatory proteins. Biochem J 348 315-320 (2000).

4 McGahan, M.C., Harned, J., Mukunnemkeril, M., et al. Iron alters glutamate secretion by regulating cytosolic aconitase activity. Am J Physiol Cell Physiol 288 1117-1124 (2005).

Formal Name	3-carboxy-3-deoxy-2-pentulosaric acid, trisodium salt
CAS Number	89304-26-7
Molecular Formula	C₆H₆O₈ · 3Na
Formula Weight	275.0
Formulation	A crystalline solid
Purity	≥95%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard OC(C(O)C(C(O)=O)C(C(O)=O)=O)=O

Background Reading

Festa, M., Colonna, A., Pietropaolo, C., et al. Oxalomalate, a competitive inhibitor of aconitase, modulates the RNA-binding activity of iron-regulatory proteins. Biochem J 348 315-320 (2000).

Gerber, D.E. EGFR inhibition in the treatment of non-small cell lung cancer. Drug Dev Res 69(6) 359-372 (2008).

Ruffo, A., Testa, E., Adinolfi, A., et al. Control of the citric acid cycle by glyoxylate. Mechanism of the inhibition by oxalomalate and γ-hydroxy-α-oxoglutarate. Biochem J 103 19-23 (1967).

McGahan, M.C., Harned, J., Mukunnemkeril, M., et al. Iron alters glutamate secretion by regulating cytosolic aconitase activity. Am J Physiol Cell Physiol 288 1117-1124 (2005).

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Size	Price	Quantity	Subtotal
1 mg	$15.00		$0.00
5 mg	$68.00		$0.00
10 mg	$120.00		$0.00
25 mg	$263.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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