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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Apelin-13

Cayman Chemical Item Number 13523

(CAS 217082-58-1)

Apelin-13 (CAS 217082-58-1)

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Description

The apelin gene encodes a pre-proprotein that is processed to generate bioactive peptides consisting of 36, 17, or 13 amino acids (apelin-36, apelin-17, and apelin-13, respectively). Apelin-13 is the endogenous ligand of the APJ receptor, activating this G protein-coupled receptor with an EC50 value of 0.37 nM (the EC50 values for apelin-17 and apelin-36 are 2.5 and 20 nM, respectively).1,2 It acts primarily in the periphery and central nervous system, playing important roles in regulating cardiovascular function, fluid homeostasis, hypertension, and insulin sensitivity.3 Unlike apelin-36, apelin-13 poorly blocks the entry of human immunodeficiency virus into cells.4

1 Tatemoto, K., Hosoya, M., Habata, Y., et al. Isolation and characterizaton of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun 251 471-476 (1998).

2 Lee, D.K., Cheng, R., Nguyen, T., et al. Characterization of apelin, the ligand for the APJ receptor. J Neurochem 74 34-41 (2000).

3 Kleinz, M.J., and Davenport, A.P. Emerging roles or apelin in biology and medicine. Pharmacol Ther 107 198-211 (2005).

4 Zou, M., Liu, H., Haraguchi, Y., et al. Apelin peptides block the entry of human immunodeficiency virus (HIV). FEBS Lett 473 15-18 (2000).

Formal Name L-​glutaminyl-​L-​arginyl-​L-​prolyl-​L-​arginyl-​L-​leucyl-​L-​seryl-​L-​histidyl-​L-​lysylglycyl-​L-​prolyl-​L-​methionyl-​L-​prolyl-​L-​phenylalanine
CAS Number 217082-58-1
Molecular Formula C69H111N23O16S
Formula Weight 1550.8
Formulation A crystalline solid
Purity ≥95%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=C(C1N(C([C@H]​(CCSC)​NC([C@H]​2N(C(CNC([C@H]​(CCCCN)​NC([C@@H]​(NC([C@H]​(CO)​NC([C@H]​(CC(C)​C)​NC([C@H]​(CCCNC(N)​=N)​NC([C@H]​3N(C([C@@H]​(NC([C@H]​(CCC(N)​=O)​N)​=O)​CCCNC(N)​=N)​=O)​CCC3)​=O)​=O)​=O)​=O)​CC4=CN=CN4)​=O)​=O)​=O)​CCC2)​=O)​=O)​CCC1)​N[C@H]​(C(O)​=O)​CC5=CC=CC=C5

Background Reading

Tatemoto, K., Hosoya, M., Habata, Y., et al. Isolation and characterizaton of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun 251 471-476 (1998).

Lee, D.K., Cheng, R., Nguyen, T., et al. Characterization of apelin, the ligand for the APJ receptor. J Neurochem 74 34-41 (2000).

Kleinz, M.J., and Davenport, A.P. Emerging roles or apelin in biology and medicine. Pharmacol Ther 107 198-211 (2005).

Zou, M., Liu, H., Haraguchi, Y., et al. Apelin peptides block the entry of human immunodeficiency virus (HIV). FEBS Lett 473 15-18 (2000).

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Size Price Quantity Subtotal
1 mg $42.00 $0.00
5 mg $189.00 $0.00
10 mg $336.00 $0.00
25 mg $735.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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