13529 eIF4B Peptide Affinity-Purified Polyclonal Antibody (aa 570-630)
Eukaryotic Translation Initiation Factor-4B
eIF4B Peptide Affinity-Purified Polyclonal Antibody (aa 570-630) Workbook Links
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Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.
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Antigen:
synthetic peptide from human eIF4B within the region of amino acids 570-630
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Host:
rabbit
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Application(s):
WB
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Eukaryotic initiation factor-4B peptide (eIF4B) is a multidomain eIF with a range of activities. It contains one RNA recognition motif (RRM) domain, a consensus RNA-binding site (RNP-CS) near the N terminus, and a central domain rich in aspartic acid, arginine, tyrosine, and glycine (DRYG). The DRYG domain of eIF4B helps in self-association and interaction with the p170 subunit of eIF3. eIF4B binds to both mRNA and 18S ribsomal RNA and thus acts as a bridge between the mRNA and the 40S ribosomal subunit during translation initiation. The ATPase and RNA helicase activity of the DEAD box protein eIF4A is stimulated by EIF4B and thus functions in close association with eIF4F, a heterotrimeric protein that binds to mRNA cap structure and unwinds inhibitory secondary structure in the 5’ untranslated region of eucaryotic mRNAs in an ATP-dependent manner. Ubiquitous expression is seen in most tissues.
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Purchase 13529 eIF4B Peptide Affinity-Purified Polyclonal Antibody (aa 570-630)
Pricing is for North America only. Other customers should contact a distributor in their region.
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Warning This product is not for human or veterinary use.
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Pricing updated 2010-03-13.
Prices are subject to change without notice.
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