Bicyclo Prostaglandin E1

Bicyclo Prostaglandin E₁

Cayman Chemical Item Number 13530

Bicyclo PGE₁

Description

Bicyclo Prostaglandin E₁ (bicyclo PGE₁) is a stable, base-catalyzed transformation product of the PGE₁ metabolite 13,14-dihydro-15-keto PGE₁. Bicyclo PGE₁ is a stable, base-catalyzed transformation product of the PGE₁ metabolite 13,14-dihydro-15-keto PGE₁. 13,14-dihydro-15-keto PGE₁ itself is a metabolite of PGE₁^1,2 found in human plasma at a median level of 10 pg/ml.³ Due to the inherent instability of 13,14-dihydro-15-keto PGE₁, it is advisable to quantify it as bicyclo PGE₁ to estimate PGE₁ biosynthesis or metabolism in vivo.

1 Hamberg, M., and Samuelsson, B. On the metabolism of prostaglandins E₁ and E₂ in man. J Biol Chem 246 6713-6721 (1971).

2 Peskar, B.A., Cawello, W., Rogatti, W., et al. On the metabolism of prostaglandin E₁ administered intravenously to human volunteers. J Physiol Pharmacol 42 327-331 (1991).

3 Leonhardt, A., Krauss, M., Gieler, U., et al. In vivo formation of prostaglandin E₁ and prostaglandin E₂ in atopic dermatitis. Br J Dermatol 136 337-340 (1997).

Synonyms

Bicyclo PGE1

Formal Name

11-deoxy-13,14-dihydro-15-keto-11β,16ξ-cycloprostaglandin E1

Molecular Formula

C₂₀H₃₂O₄

Formula Weight

336.5

Formulation

A solution in methyl acetate

Purity

>98%

Stability

1 year

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

SMILES

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CCCCC1([H])C(CC[C@H]([C@H]2CCCCCCC(O)=O)[C@@H]1CC2=O)=O

Background Reading

Hamberg, M., and Samuelsson, B. On the metabolism of prostaglandins E₁ and E₂ in man. J Biol Chem 246 6713-6721 (1971).

Peskar, B.A., Cawello, W., Rogatti, W., et al. On the metabolism of prostaglandin E₁ administered intravenously to human volunteers. J Physiol Pharmacol 42 327-331 (1991).

Leonhardt, A., Krauss, M., Gieler, U., et al. In vivo formation of prostaglandin E₁ and prostaglandin E₂ in atopic dermatitis. Br J Dermatol 136 337-340 (1997).

Bicyclo Prostaglandin E1 is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size

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Quantity

Subtotal

1 mg 
$64.00

$0.00

5 mg 
$288.00

$0.00

10 mg 
$512.00

$0.00

50 mg 
$2,240.00

$0.00

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Bicyclo Prostaglandin E₁