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(−)-Warfarin

Cayman Chemical Item Number 13531

(S)-Warfarin (CAS 5543-57-7)

(-)-Warfarin (CAS 5543-57-7)

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Description

Warfarin is an anti-coagulant used to prevent heart attacks, strokes and the formation of blood clots. It interferes with the use of vitamin K in the required carboxylation of several vitamin K-dependent proteins in the clotting cascade, preventing the initiating of clotting.1 (±)-Warfarin is a racemic mixture of two optically active isomers. (−)-Warfarin differs from (+)-warfarin by being five times more potent as a vitamin K antagonist.1 However, the two isomers are metabolized in vivo by different pathways, and (−)-warfarin has a shorter terminal elimination half-life (24-33 hours) than (+)-warfarin (35-58 hours).2

1 Hirsh, J., Fuster, V., Ansell, J., et al. American heart association/american college of cardiology foundation guide to warfarin therapy. J Am Coll Cardiol 41 1633-1652 (2003).

2 Ufer, M. Comparative pharmacokinetics of vitamin K antagonists warfarin, phenprocoumon and acenocoumarol. Clin Pharmacokinet 44(12) 1227-1246 (2005).

Synonyms
  • (S)-Warfarin
Formal Name 4-​hydroxy-​3-​[(1S)-​3-​oxo-​1-​phenylbutyl]-​2H-​1-​benzopyran-​2-​one
CAS Number 5543-57-7
Molecular Formula C19H16O4
Formula Weight 308.3
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CC(=O)​C[C@@H]​(c1ccccc1)​c1c(=O)​oc2ccccc2c1O

Background Reading

Hirsh, J., Fuster, V., Ansell, J., et al. American heart association/american college of cardiology foundation guide to warfarin therapy. J Am Coll Cardiol 41 1633-1652 (2003).

Ufer, M. Comparative pharmacokinetics of vitamin K antagonists warfarin, phenprocoumon and acenocoumarol. Clin Pharmacokinet 44(12) 1227-1246 (2005).
Size Price Quantity Subtotal
1 mg $100.00 $0.00
5 mg $450.00 $0.00
10 mg $800.00 $0.00
25 mg $1,750.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Related Products

(+)-Warfarin
(±)-Warfarin

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