eIF4B Polyclonal Antibody (aa 150-200)

Cayman Chemical Item Number 13550

Eukarytoic Translation Initiation Factor-4B

Description

Antigen: synthetic peptide from human eIF4B within the region of amino acids 150-200 · Host: rabbit · Application(s): WB · Peptide sequence: amino acids 150-200 · Eukaryotic translation initiation factor-4B (eIF4B) is a multidomain eIF with a range of activities. It contains one RNA recognition (RRM) domain, a consensus RNA-binding site (RNP-CS) near the N-terminus, and a central domain rich in aspartic acid, arginine, tyrosine, and glycine (DRYG). The DRYG domain of eIF4B helps in self-association and interaction with the p170 subunit of eIF3. eIF4B binds to both mRNA and 18S ribosomal RNA and thus acts as a bridge between the mRNA and the 40S ribosomal subunit during translation initiation. The ATPase and RNA helicase activity of the DEAD box protein eIF4A is stimulated by eIF4B and thus functions in close assocation with eIF4F. A heterotrimeric protein that binds to the mRNA cap structure and unwinds inhibitory secondary structure in the 5’ untranslated region of eukaryotic mRNAs in an ATP-dependent manner. Ubiquitous expression is seen in most of the tissues.

Synonyms

Eukarytoic Translation Initiation Factor-4B

Formulation

100 µg of affinity-purified IgG in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide

Stability

6 months

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

Specificity

Bovine eIF4B	+
Chicken eIF4B	+
Human eIF4B	+
Orangutan eIF4B	+
Rat eIF4B	+

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Size

Price

Quantity

Subtotal

1 ea

$234.00

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eIF4B Polyclonal Antibody (aa 150-200)