PRMT4 Polyclonal Antibody

Cayman Chemical Item Number 13552

CARM1; Protein Arginine Methyltransferase 4

PRMT4 Polyclonal Antibody

See more	Western Blot (557) Antibodies (630) Proteins (180) Cancer (606) Chromatin Research (137) Gene Regulation (173) Histone Modification (126)

Description

Antigen: human PRMT4 amino acid sequences 45-69 and 595-608 · Host: rabbit · Application(s): WB · Protein arginine methylation is an important post-translational modification in eukaryotic cells, which has been implicated in RNA processing and trafficking, receptor-mediated signaling, and transcription. PRMT4, also known as coactivator-associated arginine methyltransferase-1 (CARM1), belongs to a family of proteins that catalyzes the methylation of arginine residues. The PRMT proteins are recuited by C-terminal activation domain-2 of the steroid receptor coactivator (SRC) GRIP-1, whereas p300 interacts with activation domain-1 in the C-terminus. CARM1 can methylate histone H3 in vitro, and a mutation in the putative S-adenosylmethionine binding domain of CARM1 substantially reduces both methyltransferase and coactivator activities suggesting the coactivator-mediated methylation of proteins in the transcription machinery may contribute to transcriptional regulation.

Synonyms

CARM1
Protein Arginine Methyltransferase 4

Formulation

100 µg of protein G-purified IgG in 200 µl of PBS containing 0.05% BSA and 0.05% mg/ml sodium azide

Stability

1 year

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

Specificity

Human PRMT4

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1 ea	$224.00		$0.00
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Pricing updated 2012-02-12. Prices are subject to change without notice.

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PRMT4 Polyclonal Antibody

PRMT4 Polyclonal Antibody

Description

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