LSD1 Polyclonal Antibody (aa 800-850)

Cayman Chemical Item Number 13555

LSD1 Polyclonal Antibody (aa 800-850)

Description

Antigen: synthetic peptide from human LSD1 with the range of amino acids 800-850 · Host: rabbit · Application(s): WB and IHC (paraffin-embedded sections) · LSD1, the first known lysine-specific histone demethylase, is an 886 amino acid nuclear protein belonging to the flavin monoamine oxidase family. It contains a SWIRM domain, a FAD-binding motif and an amine oxidase domain. This protein is ubiquitously expressed and is a component of several histone deacetylase complexes. LSD1 acts as a component of the CoREST and other transcriptional co-repressor complexes and also plays an important role in silencing neuronal-specific genes in non-neuronal cells. It is also known to demethylate Lys4 of histone H3, a specific tag for epigenetic transcriptional activation. Reports suggest that LSD1 plays an important role in stimulating androgen-receptor-dependent transcription converting oxygen to hydrogen peroxide (might use alternative electron acceptors). Along with nuclear FHL2, it serves as a novel biomarker predictive for prostate cancer.

Formulation

100 µg of protein G-purified IgG in 200 µl PBS containing 0.2% gelatin and 0.05% sodium azide

Stability

1 year

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

Specificity

Canine LSD1	+
Human LSD1	+
Mouse LSD1	+
Rat LSD1	+
Rhesus monkey LSD1	+

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Size

Price

Quantity

Subtotal

1 ea

$224.00

$0.00

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$0.00

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LSD1 Polyclonal Antibody (aa 800-850)