PARP (Cleaved) Monoclonal Antibody
Cayman Chemical Item Number 13557
PARP (Cleaved) Monoclonal Antibody
Description
Antigen:
synthetic peptide containing amino acids near the 214/215 cleavage site of human PARP
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Host:
Mouse
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Isotype:
IgG2bκ
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Application(s):
WB and FC (intracellular)
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The poly (ADP-ribose) polymerase (PARP) is involved in cell recovery from DNA damage, such as methylation of N3-adenine, which activates the base excision repair process. PARP is a 116 kDa nuclear chromatin-associated enzyme that is cleaved during apoptosis by caspase-3 into a 24 kDa fragment containing the DNA binding domain and an 89 kDa fragment containing the catalytic and automodification domains. The 24 kDa fragment irreversibly binds to DNA and may contribute to the irreversibility of apoptosis by blocking the access of DNA repair enzymes to DNA strand breaks.
| Formulation |
100 µg protein G-purified IgG in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide |
| Stability |
1 year |
| Storage |
-20°C |
| Shipping |
Wet ice
in continental US; may vary elsewhere
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| Specificity |
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Pricing updated 2012-02-12.
Prices are subject to change without notice.
To ask for assistance with one of our products please contact a Technical Support Scientist.
Warning This product is not for human or veterinary use.
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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.
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