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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

(±)-Warfarin

Cayman Chemical Item Number 13566

Coumadin; Zoocoumarin; Coumafene; Athrombine K; WARF 42 (CAS 81-81-2)

(±)-Warfarin (CAS 81-81-2)

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Description

Warfarin is an anti-coagulant used to prevent heart attacks, strokes, and the formation of blood clots. It interferes with the use of vitamin K in the required carboxylation of several vitamin K-dependent proteins in the clotting cascade, preventing the initiating of clotting.1 (±)-Warfarin is a racemic mixture of 2 optically active isomers. (±)-Warfarin has a half-life of 36-42 hours in circulation,2 bound to plasma proteins, and accumulates in the liver, where the two isomers are metabolized by different pathways.3 Genetic differences in metabolic enzymes, drugs, diet, and disease state can affect the clearance, and thus the response, to warfarin. As a result, levels of the two enantiomers must be monitored carefully. (±)-Warfarin is also used as a rodenticide.

1 Hirsh, J., Fuster, V., Ansell, J., et al. American heart association/american college of cardiology foundation guide to warfarin therapy. J Am Coll Cardiol 41 1633-1652 (2003).

2 Ufer, M. Comparative pharmacokinetics of vitamin K antagonists warfarin, phenprocoumon and acenocoumarol. Clin Pharmacokinet 44(12) 1227-1246 (2005).

3 Toon, S., Low, L.K., Gibaldi, M., et al. The warfarin-sulfinpyrazone interaction: Stereochemical considerations. Clin Pharmacol Ther 39 15-24 (1986).

Synonyms
  • Coumadin
  • Zoocoumarin
  • Coumafene
  • Athrombine K
  • WARF 42
Formal Name 4-​hydroxy-​3-​(3-​oxo-​1-​phenylbutyl)-​2H-​1-​benzopyran-​2-​one
CAS Number 81-81-2
Molecular Formula C19H16O4
Formula Weight 308.3
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=C1OC2=CC=CC=C2C(O)​=C1C(C3=CC=CC=C3)​CC(C)​=O

(±)-Warfarin is available in the following screening library:

Size Price Quantity Subtotal
100 mg $11.00 $0.00
250 mg $26.00 $0.00
500 mg $50.00 $0.00
1 g $88.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

Acenocoumarol
(R)-(+)-Acenocoumarol
(S)-(−)-Acenocoumarol
(−)-Warfarin
(+)-Warfarin
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