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13,14-dihydro-15-keto-tetranor Prostaglandin F Exclusive

Cayman Chemical Item Number 13571

(CAS 24379-94-0)

13,14-dihydro-15-keto-tetranor Prostaglandin F1α (CAS 24379-94-0)

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Description

The metabolism of F series prostaglandins (PGs), including PGF and PGF, commonly begins with the reduction of the double bond between C-13 and C-14 and oxidation of the hydroxyl group at C-15, producing 13,14-dihydro-15-keto PGs. The removal of four carbons at the α-terminus and oxidation of the terminal ω carbon produces the abundant urinary metabolites, including tetranor-PGFM.1,2,3,4 13,14-dihydro-15-keto tetranor PGF is a potential metabolite of either PGF or PGF and likely precursor to tetranor-PGFM.

1 Granström, E., and Samuelsson, B. The structure of a urinary metabolite of prostaglandin F in man. J Am Chem Soc 91 3398-3400 (1969).

2 Granström, E., and Samuelsson, B. On the metabolism of prostaglandin F in female subjects. J Biol Chem 246 5254-5263 (1971).

3 Hamberg, M. Quantitative studies on prostaglandin synthesis in man III. Excretion of the major urinary metabolite of prostaglandins F and F during pregnancy. Life Sci 14 247-252 (1974).

4 Hamberg, M. Quantitative studies on prostaglandin synthesis in man II. Determination of the major urinary metabolite of prostaglandins F and F. Anal Biochem 55 368-378 (1973).

Formal Name 9α,​11α-​dihydroxy-​15-​oxo-​2,​3,​4,​5-​tetranor prostanoic acid
CAS Number 24379-94-0
Molecular Formula C16H28O5
Formula Weight 300.4
Formulation A solution in ethanol
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O[C@H]​1[C@H]​(CCC(CCCCC)​=O)​[C@@H]​(CCC(O)​=O)​[C@@H]​(O)​C1

Background Reading

Granström, E., and Samuelsson, B. The structure of a urinary metabolite of prostaglandin F in man. J Am Chem Soc 91 3398-3400 (1969).

Hamberg, M. Quantitative studies on prostaglandin synthesis in man III. Excretion of the major urinary metabolite of prostaglandins F and F during pregnancy. Life Sci 14 247-252 (1974).

Hamberg, M. Quantitative studies on prostaglandin synthesis in man II. Determination of the major urinary metabolite of prostaglandins F and F. Anal Biochem 55 368-378 (1973).

Granström, E., and Samuelsson, B. On the metabolism of prostaglandin F in female subjects. J Biol Chem 246 5254-5263 (1971).

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Size Price Quantity Subtotal
10 µg $80.00 $0.00
25 µg $190.00 $0.00
50 µg $360.00 $0.00
100 µg $640.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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