Toll-Like Receptor 1 Polyclonal Antibody

Cayman Chemical Item Number 13582

TLR1

Toll-Like Receptor 1 Polyclonal Antibody

Description

Antigen: synthetic peptide from human TLR1 amino acids 400-450 · Host: rabbit · Application(s): WB and FC (intracellular and cell surface) · The toll-like receptors (TLRs) in mammals comprise a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an interleukin-1 (IL-1) receptor motif in the cytoplasmic domain. Like their counterparts in Drosophila, TLRs signal through adaptor molecules.¹ The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition.² Most mammalian species have between ten and fifteen types of TLRs. Ten functional TLRs (TLR1-10) have been identified in human. Humans also encode a TLR11 gene but it contains several stop codons and protein is not expressed. However, mouse and rat TLR11 are functional, and it is thought that human TLR11 function was lost during evolution. TLR2 is differentially expressed in human cells. Historically speaking, TLR expression has been most extensively studied in the immune system. Overall, TLRs are highly expressed in immune competent cells, including macrophages, dendritic cells, neutrophils, mucosal epithelial cells and dermal endothelial cells. However, TLRs have also been identified in many other cell types and anatomical tissue locations where they are expressed either constitutively or induced during infection. In mice, TLR1 interacts with TLR2 and coexpression of TLR1 and TLR2 enhances the NF-kB activation in response to a synthetic lipopeptide. Together, they recognize the lipid configuration of the native mycobacterial lipoprotein as well as several triacylated lipopeptides.

1 Srivastava, M.D., and Srivastava, B.I.S. Expression of mRNA and proteins for toll-like receptors, associated molecules, defensins and LL-37 by SRIK-NKL, a CD8+ NK/T cell line. Leuk Res 7 813-820 (2005).

2 Gibson, F.C., Hong, C., Chou, H., et al. Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation 109 2801-2806 (2004).

Synonyms

TLR1

Formulation

0.1 mg of protein G-purified in 0.2 ml PBS containing 0.05% BSA and 0.05% sodium azide

Stability

1 year

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

Specificity

Human TLR1	+
Mouse TLR1	+
Rat TLR1	+

Background Reading

Srivastava, M.D., and Srivastava, B.I.S. Expression of mRNA and proteins for toll-like receptors, associated molecules, defensins and LL-37 by SRIK-NKL, a CD8+ NK/T cell line. Leuk Res 7 813-820 (2005).

Gibson, F.C., Hong, C., Chou, H., et al. Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation 109 2801-2806 (2004).

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1 ea

$249.00

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