13584 Toll-Like Receptor 10 Monoclonal Antibody (Clone 158C1114)
TLR10
Toll-Like Receptor 10 Monoclonal Antibody (Clone 158C1114) Workbook Links
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Antigen:
synthetic peptide from the extracellular domain of human TLR10
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Clone designation:
158C1114
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Host:
Mouse
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Isotype:
IgG1
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Application(s):
WB and FC (intracellular and cell surface)
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The toll-like receptors (TLRs) in mammals comprise a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an interleukin-1 (IL-1) receptor motif in the cytoplasmic domain. Like their counterparts in Drosophila, TLRs signal through adaptor molecules.1 The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition.2 Most mammalian species have between ten and fifteen types of TLRs. Ten functional TLRs (TLR1-10) have been identified in human. Humans also encode a TLR11 gene but it contains several stop codons and protein is not expressed. However, murine and rat TLR11 are functional, and it is thought that human TLR11 function was lost during evolution. Historically speaking, TLR expression has been most extensively studied in the immune system. Overall, TLRs are highly expressed in immune competent cells, including macrophages, dendritic cells, neutrophils, mucosal epithelial cells, and dermal endothelial cells. However, TLRs have also been identified in many other cell types and anatomical tissue locations where they are expressed either constitutively or induced during infection. The human TLR10 gene codes for a protein containing 811 amino acids. Human TLR10 is closely related to human TLR1 and TLR6. TLR10 is expressed in tissues and cells of the immune system.
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1
Srivastava, M.D., Srivastava, B.I.S. Expression of mRNA and proteins for toll-like receptors, associated molecules, defensins and LL-37 by SRIK-NKL, a CD8+ NK/T cell line. Leukemia Research 7 813-820 (2005).
2
Gibson, F.C., Hong, C., Chou, H., et al. Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation 109 2801-2806 (2004).
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Purchase 13584 Toll-Like Receptor 10 Monoclonal Antibody (Clone 158C1114)
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Pricing updated 2010-03-14.
Prices are subject to change without notice.
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