13591 Toll-Like Receptor 7 Polyclonal Antibody
TLR7
Toll-Like Receptor 7 Polyclonal Antibody Workbook Links
Cayman offers a variety of analysis tools to assist you.
Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.
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Antigen:
synthetic peptide from human TLR7 within the region of amino acids 706-728
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Host:
rabbit
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Application(s):
WB, FC (intracellular and cell surface), IHC (frozen and paraffin), ICC, and IP
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The toll-like receptors (TLRs) in mammals comprise a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an interleukin-1 (IL-1) receptor motif in the cytoplasmic domain. Like their counterparts in Drosophila, TLRs signal through adaptor molecules.1 The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition.2 Most mammalian species have between ten and fifteen types of TLRs. Ten functional TLRs (TLR1-10) have been identified in human. Humans also encode a TLR11 gene but it contains several stop codons and protein is not expressed. However, mouse and rat TLR11 are functional, and it is thought that human TLR11 function was lost during evolution. Historically speaking, TLR expression has been most extensively studied in the immune system. Overall, TLRs are highly expressed in immune competent cells, including macrophages, dendritic cells, neutrophils, mucosal epithelial cells and dermal endothelial cells. However, TLRs have also been identified in many other cell types and anatomical tissue locations where they are expressed either constitutively or induced during infection. Stimulation of the NF-κB signaling pathway by TLR7 suggests that it plays a role in immune response.
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1
Srivastava, M.D., Srivastava, B.I.S. Expression of mRNA and proteins for toll-like receptors, associated molecules, defensins and LL-37 by SRIK-NKL, a CD8+ NK/T cell line. Leukemia Research 7 813-820 (2005).
2
Gibson, F.C., Hong, C., Chou, H., et al. Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation 109 2801-2806 (2004).
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Purchase 13591 Toll-Like Receptor 7 Polyclonal Antibody
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Warning This product is not for human or veterinary use.
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Pricing updated 2010-03-14.
Prices are subject to change without notice.
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