13595 Toll-Like Receptor 5 Monoclonal Antibody (Clone 85B152.5)
TLR5
Toll-Like Receptor 5 Monoclonal Antibody (Clone 85B152.5) Workbook Links
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Antigen:
synthetic peptide corresponding to a portion of human TLR5
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Clone designation:
85B152.5
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Host:
mouse
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Isotype:
IgG2a
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Application(s):
WB and FC (intracellular and cell surface)
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The toll-like receptors (TLRs) in mammals comprise a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an interleukin-1 (IL-1) receptor motif in the cytoplasmic domain. Like their counterparts in Drosophila, TLRs signal through adaptor molecules.1 The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition.2 Most mammalian species have between ten and fifteen types of TLRs. Ten functional TLRs (TLR1-10) have been identified in human. Humans also encode a TLR11 gene but it contains several stop codons and protein is not expressed. However, mouse and rat TLR11 are functional, and it is thought that human TLR11 function was lost during evolution. Historically speaking, TLR expression has been most extensively studied in the immune system. Overall, TLRs are highly expressed in immune competent cells, including macrophages, dendritic cells, neutrophils, mucosal epithelial cells and dermal endothelial cells. However, TLRs have also been identified in many other cell types and anatomical tissue locations where they are expressed either constitutively or induced during infection. TLR5 expression is upregulated following exposure to bacteria or to the TLR5 agonist, flagellin. Gram-negative bacteria stimulate monocyte/macrophage cells in a TLR5-specific, CD14-independent manner. TLR5 thus appears to be the principal means by which the innate immune system recognizes flagellated bacterial pathogens.
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1
Srivastava, M.D., Srivastava, B.I.S. Expression of mRNA and proteins for toll-like receptors, associated molecules, defensins and LL-37 by SRIK-NKL, a CD8+ NK/T cell line. Leukemia Research 7 813-820 (2005).
2
Gibson, F.C., Hong, C., Chou, H., et al. Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation 109 2801-2806 (2004).
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Purchase 13595 Toll-Like Receptor 5 Monoclonal Antibody (Clone 85B152.5)
Pricing is for North America only. Other customers should contact a distributor in their region.
This product is also available to buy in bulk quantities.
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for a quote or to purchase.
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Warning This product is not for human or veterinary use.
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Pricing updated 2010-03-14.
Prices are subject to change without notice.
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