13609 13,14-dihydro-16,16-difluoro Prostaglandin F2α
13,14-dihydro-16,16-difluoro PGF2α
13,14-dihydro-16,16-difluoro Prostaglandin F2α Workbook Links
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Prostaglandin F2α (PGF2α) causes contraction of vascular, bronchial, intestinal, and myometrial smooth muscle, and also exhibits potent luteolytic activity.1,2
13,14-dihydro-16,16-difluoro PGF2α is an analog of PGF2α. While its biological activities have not been evaluated, it should be noted that the addition of two electron-withdrawing fluorine atoms has been used to stabilize prostanoids and significantly delay degradation in vivo.3 Importantly, 13,14-dihydro PGE1 has activity that is comparable to that of PGE1, suggesting that this analog of PGF2α could be biologically active.4,5
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1
Samuelsson, B., Goldyne, M., Granström, E., et al. Prostaglandins and thromboxanes. Annu Rev Biochem 47 997-1029 (1978).
2
Basu, S. Novel cyclooxygenase-catalyzed bioactive prostaglandin F2α from physiology to new principles in inflammation. Medicinal Research Reviews 27(4) 435-468 (2007).
3
Hatano, Y., Kohli, J.D., Goldberg, L.I., et al. Vascular relaxing activity and stability studies of 10,10-difluoro-13,14-dehydroprostacyclin. Proc Natl Acad Sci USA 77(11) 6846-6850 (1980).
4
Änggård, E. The biological activities of three metabolites of prostaglandin E1. Acta Physiol Scand 66 509-510 (1966).
5
Hamberg, M., Samuelsson, B. On the metabolism of prostaglandins E1 and E2 in man. J Biol Chem 246 6713-6721 (1971).
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Purchase 13609 13,14-dihydro-16,16-difluoro Prostaglandin F2α
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Pricing updated 2010-03-19.
Prices are subject to change without notice.
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Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.
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