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CAY10614 Exclusive

Cayman Chemical Item Number 13615

(CAS 1202208-36-3)

CAY10614 (CAS 1202208-36-3)

See more	Inhibitors (493) Immunology (181) Infectious Disease (64) Inflammation (383) Sepsis/Shock (22)

Description

Lipid A is a lipid-rich component of endotoxin, also known as lipopolysaccharide (LPS), which in turn is part of the outer membrane of Gram-negative bacteria. Lipid A activates toll-like receptor 4 (TLR4), initiating an immune response. CAY10614 is an antagonist of lipid A activation of TLR4, exhibiting an IC₅₀ value of 1.68 μM in a cell-based assay using modified human embryonic kidney (HEK) cells.¹ It does not significantly affect HEK cell viability. In a model of sepsis, CAY10614 dramatically and significantly improves survival of mice given intraperitoneal LPS.¹

1 Piazza, M., Rossini, C., Fiorentina, S.D., et al. Glycolipids and benzylammonium lipids as novel antisepsis agents: Synthesis and biological characterization. J Med Chem 52 1209-1213 (2009).

Formal Name	N-cyclopentyl-N,N-dimethyl-3,4-bis(tetradecyloxy)-benzenemethanaminium, iodide
CAS Number	1202208-36-3
Molecular Formula	C₄₂H₇₈INO₂
Formula Weight	756.0
Formulation	A crystalline solid
Purity	≥98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCCCCCCCCCCOC1=CC=C(C[N+](C)(C)C2CCCC2)C=C1OCCCCCCCCCCCCCC.[I-]

Background Reading

Piazza, M., Rossini, C., Fiorentina, S.D., et al. Glycolipids and benzylammonium lipids as novel antisepsis agents: Synthesis and biological characterization. J Med Chem 52 1209-1213 (2009).

Size	Price	Quantity	Subtotal
1 mg	$43.00		$0.00
5 mg	$194.00		$0.00
10 mg	$344.00		$0.00
25 mg	$753.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-11. Prices are subject to change without notice.

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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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