Cayman Chemical | ACS 67 | Description (CAS 1088434-86-9)

13619 ACS 67

(CAS 1088434-86-9)

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• See more Hydrogen Sulfide Donor; Prostaglandins; Ophthalmology

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Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug for the treatment of glaucoma.¹ Latanoprost is an isopropyl ester, a prodrug form which is converted to latanoprost (free acid) by endogenous esterase enzymes. The free acid form is 200 times more potent than latanoprost as an FP receptor ligand for the human recombinant FP receptor.² ACS 67 is an analog of latanoprost (free acid) that contains a hydrogen sulfide releasing component conjugated to the latanoprost carboxyl group.³ In glaucomatous pigmented rabbits, ACS 67 reduced intra-ocular pressure (IOP) more rapidly and to a greater extent than latanoprost (15 versus 25.5 mm Hg at 4 hours) at a dose of 0.005% for each compound.³ ACS 67 also increased the levels of reduced glutathione and cGMP in the aqueous humor of glaucomatous pigmented rabbits better than latanoprost.³

1 Stjernschantz, J., Resul, B. Phenyl substituted prostaglandin analogs for glaucoma treatment. Drugs of the Future 17 691-704 (1992).

2 Abramovitz, M., Adam, M., Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta 1483 285-293 (2000).

3 Perrino, E., Uliva, C., Lanzi, C., et al. New prostaglandin derivative for glaucoma treatment. Bioorg Medicinal Chem Letters 19 1639-1642 (2009).

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Pricing updated 2010-03-19.
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