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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

ACS 67 Exclusive

Cayman Chemical Item Number 13619

(CAS 1088434-86-9)

ACS 67 (CAS 1088434-86-9)

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Description

Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug for the treatment of glaucoma.1 Latanoprost is an isopropyl ester, a prodrug form which is converted to latanoprost (free acid) by endogenous esterase enzymes. The free acid form is 200 times more potent than latanoprost as an FP receptor ligand for the human recombinant FP receptor.2 ACS 67 is an analog of latanoprost (free acid) that contains a hydrogen sulfide releasing component conjugated to the latanoprost carboxyl group.3 In glaucomatous pigmented rabbits, ACS 67 reduced intra-ocular pressure (IOP) more rapidly and to a greater extent than latanoprost (15 versus 25.5 mm Hg at four hours) at a dose of 0.005% for each compound.3 ACS 67 also increased the levels of reduced glutathione and cGMP in the aqueous humor of glaucomatous pigmented rabbits better than latanoprost.3

1 Stjernschantz, J., and Resul, B. Phenyl substituted prostaglandin analogs for glaucoma treatment. Drugs Future 17 691-704 (1992).

2 Abramovitz, M., Adam, M., Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta 1483 285-293 (2000).

3 Perrino, E., Uliva, C., Lanzi, C., et al. New prostaglandin derivative for glaucoma treatment. Bioorg Med Chem Lett 19 1639-1642 (2009).

Formal Name 7-​[(1R,​2R,​3R,​5S)-​3,​5-​dihydroxy-​2-​[(3R)-​3-​hydroxy-​5-​phenylpentyl]cyclopentyl]-​4-​(3-​thioxo-​3H-​1,​2-​dithiol-​5-​yl)phenyl ester,​ 5Z-​heptenoic acid
CAS Number 1088434-86-9
Molecular Formula C32H38O5S3
Formula Weight 598.8
Formulation A crystalline solid
Purity ≥95%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O[C@@H]​1[C@H]​(C/C=C\CCCC(OC2=CC=C(C3=CC(SS3)​=S)​C=C2)​=O)​[C@@H]​(CC[C@@H]​(O)​CCC4=CC=CC=C4)​[C@H]​(O)​C1

Background Reading

Perrino, E., Uliva, C., Lanzi, C., et al. New prostaglandin derivative for glaucoma treatment. Bioorg Med Chem Lett 19 1639-1642 (2009).

Stjernschantz, J., and Resul, B. Phenyl substituted prostaglandin analogs for glaucoma treatment. Drugs Future 17 691-704 (1992).

Abramovitz, M., Adam, M., Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta 1483 285-293 (2000).
Size Price Quantity Subtotal
1 mg $63.00 $0.00
5 mg $284.00 $0.00
10 mg $504.00 $0.00
25 mg $1,103.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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