Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Pristimerin Exclusive

Cayman Chemical Item Number 13621

Celastrol methyl ester; NSC 99281 (CAS 1258-84-0)

Pristimerin (CAS 1258-84-0)

See more	Cannabinoids (296) Inhibitors (493) Neuroscience (654) Pain (144)

Description

Monoacylglycerol lipase (MAGL) hydrolyzes the endogenous cannabinoid 2-arachidonoyl glycerol (2-AG), terminating its capacity to activate cannabinoid receptors. Pristimerin is a naturally occurring terpenoid that potently inhibits MAGL (IC₅₀ = 93 nM).¹ Its actions are rapid, reversible, and noncompetitive.¹ Pristimerin (1 µM) significantly increases 2-AG levels in isolated rat neurons,¹ indicating that it inhibits endogenous MAGL in cultured cells. Moreover, it does not increase levels of palmitoyl ethanolamide, suggesting that pristimerin does not affect the activity of fatty acid amide hydrolase (FAAH).

1 King, A.R., Dotsey, E.Y., Lodola, A., et al. Discovery of potent and reversible monoacylglycerol lipase inhibitors. Chem Biol 16 1045-1052 (2009).

Synonyms	Celastrol methyl ester NSC 99281
Formal Name	3-hydroxy-9β,13α-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid, methyl ester
CAS Number	1258-84-0
Molecular Formula	C₃₀H₄₀O₄
Formula Weight	464.6
Formulation	A crystalline solid
Purity	≥98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O=C1C(O)=C(C)C2=CC=C([C@](CC[C@]3(C)C4C[C@@](C(OC)=O)(C)CC3)(C)[C@@]4(C)CC5)[C@]5(C)C2=C1

Background Reading

King, A.R., Dotsey, E.Y., Lodola, A., et al. Discovery of potent and reversible monoacylglycerol lipase inhibitors. Chem Biol 16 1045-1052 (2009).

Size	Price	Quantity	Subtotal
5 mg	$102.00		$0.00
10 mg	$194.00		$0.00
25 mg	$459.00		$0.00
50 mg	$816.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Celastrol

Fatty Acid Amide Hydrolase (human recombinant)

JZL 184

Monoacylglycerol Lipase (human recombinant)

Palmitoyl Ethanolamide

Palmitoyl Ethanolamide-d₄ Exclusive

Show all 7 Hide all but first 3

Downloads

	Download Product Insert 123 Kb PDF
	Printer-friendly version of this page small PDF (usually less than 100 Kb)
	• US Letter paper 8½″ × 11″
	• A4 paper 21cm × 29.7cm
	Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs	Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases	Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule	Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640