JWH 019 is a cannabimimetic indole that shows a high-affinity for both the central cannabinoid (CB1) and the peripheral cannabinoid (CB2) receptors. The affinities of JWH 019 for both CB1 (Ki = 9.8 nM) and CB2 (Ki = 5.6 nM) are superior to those of the traditional cannabinoid, Δ9-tetrahydrocannabinol (Δ9-THC; Ki values of 40.7 and 36.4 nM for CB1 and CB2, respectively).1
1
Aung, M.M., Griffin, G., Huffman, J.W., et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding. Drug Alcohol Depend60133-140(2000).
Aung, M.M., Griffin, G., Huffman, J.W., et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding. Drug Alcohol Depend60133-140(2000).
JWH 019 is available in the following screening
library: