Cayman Chemical | 13,14-dihydro-16,16-difluoro Prostaglandin J2 | Description • 13,14-dihydro-16,16-difluoro PGJ2

13635 13,14-dihydro-16,16-difluoro Prostaglandin J₂

13,14-dihydro-16,16-difluoro PGJ₂

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Prostaglandin J₂ (PGJ₂) is an analog of PGD₂ that can inhibit both platelet aggregation and cell growth.^1,2,3 However, it is not clear whether these effects are initiated by PGJ₂ or a derivative. 13,14-dihydro-16,16-difluoro PGJ₂ is an analog of PGJ₂. While its biological activities have not been evaluated, it should be noted that the addition of two electron-withdrawing fluorine atoms has been used to stabilize prostanoids and significantly delay degradation in vivo.⁴ Importantly, 13,14-dihydro PGE₁ has activity that is comparable to that of PGE₁, suggesting that this analog of PGJ₂ could be biologically active.^5,6

1 Bundy, G.L., Morton, D.R., Peterson, D.C., et al. Synthesis and platelet aggregation inhibiting activity of prostaglandin D analogues. J Med Chem 26 790-799 (1983).

2 Mahmud, I., Smith, D.L., Whyte, M.A., et al. On the identification and biological properties of prostaglandin J₂. Prostaglandins Leukot Med 16 131-146 (1984).

3 Fukushima, M. Prostaglandin J₂ - antitumor and anti-viral activities and the mechanisms involved. Eicosanoids 3 189-199 (1990).

4 Hatano, Y., Kohli, J.D., Goldberg, L.I., et al. Vascular relaxing activity and stability studies of 10,10-difluoro-13,14-dehydroprostacyclin. Proc Natl Acad Sci USA 77(11) 6846-6850 (1980).

5 Änggård, E. The biological activities of three metabolites of prostaglandin E₁. Acta Physiol Scand 66 509-510 (1966).

6 Hamberg, M., Samuelsson, B. On the metabolism of prostaglandins E₁ and E₂ in man. J Biol Chem 246 6713-6721 (1971).

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Pricing updated 2010-03-11.
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Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.