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NVP-AEW541 (hydrochloride)

Cayman Chemical Item Number 13641

NVP-AEW541 (hydrochloride)

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Description

Insulin-like growth factor 1 receptor (IGF-1R) is a receptor tyrosine kinase whose activation leads to angiogenesis as well as cell proliferation, survival, transformation, and metastasis. IGF-1R signaling has been implicated in the development and progression of cancer. NVP-AEW541 is a selective IGF-1R kinase inhibitor. In vitro, it inhibits the autophosphorylation activity of IGF-1R (IC50 = 0.086 µM) and prevents IGF-1-mediated survival and proliferation of MCF-7 cells (IC50 = 0.16 and 1.64 µM, respectively).1 When tested against a panel of native tyrosine kinases, including the structurally-related insulin receptor (Ins-R), NVP-AEW541 is 27-fold more potent toward IGF-1R.1 Demonstrating positive oral bioavailabilty, NVP-AEW541 dose-dependently inhibits tumor growth in a mouse NWT-21 fibrosarcoma tumor model.1

1 García-Echeverría, C., Pearson, M.A., Marti, A., et al. In vivo antitumor activity of NVP-AEW541 - A novel, potent, and selective inhibitor of the IGF-IR kinase. Cancer Cell 5 231-239 (2004).

Formal Name 7-​[cis-​3-​(1-​azetidinylmethyl)cyclobutyl]-​5-​[3-​(phenylmethoxy)phenyl]-​7H-​pyrrolo[2,​3-​d]pyrimidin-​4-​amine,​ dihydrochloride
Molecular Formula C27H29N5O · 2HCl
Formula Weight 512.5
Formulation A crystalline solid
Purity ≥98%
λmax 288 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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NC1=C2C(N([C@H]​3C[C@H]​(CN4CCC4)​C3)​C=C2C5=CC=C(OCC6=CC=CC=C6)​C=C5)​=NC=N1

Background Reading

García-Echeverría, C., Pearson, M.A., Marti, A., et al. In vivo antitumor activity of NVP-AEW541 - A novel, potent, and selective inhibitor of the IGF-IR kinase. Cancer Cell 5 231-239 (2004).
Size Price Quantity Subtotal
500 µg $92.00 $0.00
1 mg $175.00 $0.00
5 mg $736.00 $0.00
10 mg $1,288.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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