Aspalatone is an anti-platelet aggregator (IC50 = 180 µM, in vitro) that prolongs bleeding time significantly in a rodent model of thromboembolism.1 Additionally at a minimal effective dose of 24 mg/kg, aspalatone generates antioxidant and neuroprotective effects against kainic acid-induced epilepsy in rat hippocampus.2
1
Han, B.H., Suh, D.Y., Yang, H.O., et al. Synthesis and antiplatelet effects of the new antithrombotic agent aspalatone with low ulcerogenicity. Arzneimittelforschung44(10)1122-1126(1994).
2
Kim, H., Choi, D., Jhoo, W., et al. Aspalatone, a new antiplatelet agent, attenuates the neurotoxicity induced by kainic acid in the rat. Life Sci61(24)373-381(1997).