See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Alfuzosin (hydrochloride)

Cayman Chemical Item Number 13648

Uroxatral; SL 77499-10 (CAS 81403-68-1)

Alfuzosin (hydrochloride) (CAS 81403-68-1)

See more

Description

Alfuzosin is a post-synaptic α1-adrenergic receptor antagonist commonly used to improve lower urinary tract symptoms associated with benign prostatic hyperplasia (BPH).1,2 It displays high-affinity with non-selectivity for the three known human α1 adrenoceptors (pKi = 8.0, 8.0, and 8.5 for α1A, α1B, and α1D, respectively).3Consistent with a role for α1 adrenoceptors in mediating contraction of smooth muscle, alfuzosin was first described as having anti-hypertensive effects with peripheral vasodilator properties.1 In patients with BPH, alfuzosin increases mean urinary flow rate and decreases residual volume.2 Alfuzosin produces minimal vasodilatory and sexual function side effects.4,5,6

1 Sinclair, A.J., Davies, I.B., and Warrington, S.J. Alfuzosin and the venous reflex response: Studies in normal subjects. Br J Clin Pharmacol 27 19-22 (1989).

2 Jardin, A., Bensadoun, H., Delauche-Cavallier, M.C., et al. Alfuzosin for treatment of benign prostatic hypertrophy. Lancet 337 1457-1461 (1991).

3 Kenny, B.A., Miller, A.M., Williamson, I.J.R., et al. Evaluation of the pharmacological selectivity profile of α1 adrenoceptor antagonists at prostatic α1 adrenoceptors: Binding, functional and in vivo studies. Br J Pharmacol 118 871-878 (1996).

4 Roehrborn, C.G., and Rosen, R.C. Medical therapy options for aging men with benign prostatic hyperplasia: Focus on alfuzosin 10 mg once daily. Clin Interv Aging 3(3) 511-524 (2008).

5 Nickel, J.C., Sander, S., and Moon, T.D. A meta-analysis of the vascular-related safety profile and efficacy of α-adrenergic blockers for symptoms related to benign prostatic hyperplasia. Int J Clin Pract 62(10) 1547-1559 (2008).

6 Michel, M.C. The forefront for novel therapeutic agents based on the pathophysiology of lower urinary tract dysfunction: α-blockers in the treatment of male voiding dysfunction - how do they work and why do they differ in tolerability? J Pharmacol Sci 112 151-157 (2010).

Synonyms
  • Uroxatral
  • SL 77499-10
Formal Name N-​[3-​[(4-​amino-​6,​7-​dimethoxy-​2-​quinazolinyl)methylamino]propyl]tetrahydro-​2-​furancarboxamide,​ monohydrochloride
CAS Number 81403-68-1
Molecular Formula C19H27N5O4 • HCl
Formula Weight 425.9
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
COC1=CC2=C(C(N)​=NC(N(C)​CCCNC(C3CCCO3)​=O)​=N2)​C=C1OC.Cl
Size Price Quantity Subtotal
10 mg $59.00 $0.00
50 mg $266.00 $0.00
100 mg $472.00 $0.00
500 mg $2,065.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-11. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

ARRB2 Polyclonal Antibody
Guanabenz (hydrochloride) New

Downloads

Batch-specific Information

Login to access batch-specific information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

Lost password?