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YK-4-279

Cayman Chemical Item Number 13661

(CAS 1037184-44-3)

YK-4-279 (CAS 1037184-44-3)

See more	Inhibitors (493) Apoptosis (183) Cancer (606)

Description

ES-FLI1 is an oncogenic fusion protein found in Ewing’s sarcoma, a family of undifferentiated tumors that occur throughout the body. The binding of RNA helicase A (RHA) to ES-FLI1 promotes its oncogenic function. YK-4-279 is an inhibitor of protein-protein interactions between ES-FLI1 and RHA. At 10 µM, YK-4-279 blocks RHA binding to ES-FLI1 and induces apoptosis of a panel of Ewing’s sarcoma tumor cell lines with IC₅₀ values ranging from 0.5-2 µM.¹ At 1.5 mg per dose, YK-4-279 reduces the growth of Ewing’s sarcoma orthotopic xenografts in mice after treatment with the inhibitor for two weeks.¹

1 Erkizan, H.V., Kong, Y., Merchant, M., et al. A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing’s sarcoma. Nat Med 15(7) 750-756 (2009).

Formal Name	4,7-dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-2H-indole-2-one
CAS Number	1037184-44-3
Molecular Formula	C₁₇H₁₃Cl₂NO₄
Formula Weight	366.2
Formulation	A crystalline solid
Purity	≥98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard ClC1=CC=C(Cl)C(N2)=C1C(O)(CC(C3=CC=C(OC)C=C3)=O)C2=O

Background Reading

Erkizan, H.V., Kong, Y., Merchant, M., et al. A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing’s sarcoma. Nat Med 15(7) 750-756 (2009).

Size	Price	Quantity	Subtotal
1 mg	$35.00		$0.00
5 mg	$95.00		$0.00
10 mg	$160.00		$0.00
50 mg	$700.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-09. Prices are subject to change without notice.

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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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