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JZL 195

Cayman Chemical Item Number 13668

(CAS 121004-12-8)

JZL 195 (CAS 121004-12-8)

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Sold under license from The Scripps Research Institute.

Description

Fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) mediate the hydrolysis of the endocannabinoids arachidonoyl ethanolamide (AEA) and 2-arachidonoylglycerol (2-AG), respectively. JZL 195 is a potent inhibitor of both FAAH and MAGL (IC50 = 2 and 4 nM, respectively).1 It poorly inhibits neuropathy target esterase and ABHD6 and does not inhibit other brain serine hydrolases. JZL 195 displays time-dependent inhibition of FAAH and MAGL in vivo, consistent with a covalent mechanism of activation.1 The in vivo inhibitory actions of JZL 195 against FAAH and MAGL are comparable to those of the selective inhibitors PF-3845 (Catalog No. 13279) and JZL 184 (Catalog No. 13158), respectively.1 Through its inhibitory actions, JZL 195 simultaneously augments brain levels of AEA and 2-AG, producing antinociceptive, cataleptic, and hypomotility effects like those produced by direct CB1 agonists.1

1 Long, J.Z., Nomura, D.K., Vann, R.E., et al. Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proc Natl Acad Sci USA 106(48) 20270-20275 (2009).

Formal Name 4-​nitrophenyl 4-​(3-​phenoxybenzyl)piperazine-​1-​carboxylate
CAS Number 121004-12-8
Molecular Formula C24H23N3O5
Formula Weight 433.5
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=C(OC1=CC=C([N+]​([O-]​)​=O)​C=C1)​N(CC2)​CCN2CC3=CC=CC(OC4=CC=CC=C4)​=C3

Background Reading

Long, J.Z., Nomura, D.K., Vann, R.E., et al. Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proc Natl Acad Sci USA 106(48) 20270-20275 (2009).
Size Price Quantity Subtotal
5 mg $46.00 $0.00
10 mg $87.00 $0.00
50 mg $368.00 $0.00
100 mg $644.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Monoacylglycerol Lipase Inhibitor Screening Assay Kit
PF-3845
PF-622
PF-750
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Sold under license from The Scripps Research Institute.

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