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HCN1 Cyclic Nucleotide-gated Channel Monoclonal Antibody (Clone S70-28)

Cayman Chemical Item Number 13705

See more	Immunocytochemistry (144) Immunohistochemistry (213) Receptor Biochemistry (344) Western Blot (567) Antibodies (677) Cardiology (86) Cell Biology (303) Neuroscience (725)

Description

Antigen: fusion protein amino acids 778-910 (cytoplasmic C-terminus) of rat HCN1 · Clone designation: S70-28 · Host: mouse · Isotype: IgG₁ · Application(s): WB, IP, IHC, and ICC · Hyperpolarization-activated cation channels of the HCN gene family, such as HCN1, play a crucial role in the regulation of cell excitability. Importantly, they contribute to spontaneous rhythmic activity in both the heart and brain.¹

1 Zong, X., Eckert, C., Yuan, H., et al. A novel mechanism of modulation of hyperpolarization-activated cyclic nucleotide-gated channels by src kinase. J Biol Chem 280(40) 34224-34232 (2005).

Formulation

100 µg of protein G-purified IgG in 100 µl PBS, pH 7.4, containing 50% glycerol and 0.09% sodium azide

Stability

1 year

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

Specificity

Human HCN1	+
Mouse HCN1	+
Rat HCN1	+

Background Reading

Zong, X., Eckert, C., Yuan, H., et al. A novel mechanism of modulation of hyperpolarization-activated cyclic nucleotide-gated channels by src kinase. J Biol Chem 280(40) 34224-34232 (2005).

. What are ion channels? (2004).

Hille, B. Ion Channels of Excitable Membranes. 3rd (2001).

Size	Price	Quantity	Subtotal
100 µg	$290.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

HCN2 Cyclic Nucleotide-gated Channel Monoclonal Antibody (Clone S71-37)

HCN3 Cyclic Neuclotide-gated Channel Monoclonal Antibody (Clone S141-28)

HCN4 Cyclic Nucleotide-gated Channel Monoclonal Antibody (Clone S114-10)

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Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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