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Acetyl Lysine Polyclonal Antibody-biotin

Cayman Chemical Item Number 13725

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Description

Antigen: acetylated KLH · Host: rabbit · Application(s): WB, IP, ELISA, and IF · Post-translational modifications of proteins play critical roles in the regulation and function of many known biological processes. Proteins can be post-translationally modified in many different ways, and a common post-transcriptional modification of lysine involves acetylation.1 The conserved amino-terminal domains of the four core histones (H2A, H2B, H3, and H4) contain lysines that are acetylated by histone acetyltransferases (HATs) and deacetylated by histone deacetylases (HDACs).2 Protein post-translational reversible lysine Nε-acetylation and deacetylation have been recognized as an emerging intracellular signaling mechanism that plays critical roles in regulating gene transcription, cell-cycle progession, apoptosis, DNA repair, and cytoskeletal orgnization.3 The regulation of protein acetylation status is impaired in the pathologies of cancer and polyglutamine diseases, and HDACs have become promising targets for anti-cancer drugs currently in development.4,5

1 Yang, X. Multisite protein modification and intramolecular signaling. Oncogene 24 1653-1662 (2005).

2 Hassig, C.A., and Schreiber, S.L. Nuclear histone acetylases and deacetylases and transcriptional regulation: HATs off to HDACs. Curr Opin Chem Biol 1(3) 300-308 (1997).

3 Yang, X. Lysine acetylation and the bromodomain: A new partnership for signaling. BioEssays 26(10) 1076-1087 (2004).

4 Hughes, R.E. Polyglutamine disease: Acetyltransferases awry. Curr Biol 12(4) R141-R143 (2002).

5 Vigushin, D.M., and Coombes, R.C. Targeted histone deacetylase inhibition for cancer therapy. Curr Cancer Drug Targets 4 205-218 (2004).

Formulation 400 µl (0.25 mg/ml) of rabbit immunoglobulin in PBS containing 0.01% sodium azide
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Specificity
Acetylated lysine residues +
Non-acetylated proteins -

Background Reading

Vigushin, D.M., and Coombes, R.C. Targeted histone deacetylase inhibition for cancer therapy. Curr Cancer Drug Targets 4 205-218 (2004).

Hughes, R.E. Polyglutamine disease: Acetyltransferases awry. Curr Biol 12(4) R141-R143 (2002).

Yang, X. Lysine acetylation and the bromodomain: A new partnership for signaling. BioEssays 26(10) 1076-1087 (2004).

Yang, X. Multisite protein modification and intramolecular signaling. Oncogene 24 1653-1662 (2005).

Hassig, C.A., and Schreiber, S.L. Nuclear histone acetylases and deacetylases and transcriptional regulation: HATs off to HDACs. Curr Opin Chem Biol 1(3) 300-308 (1997).

Show all 5 Hide all but first 3
Size Price Quantity Subtotal
400 µl $290.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Acetyl Lysine Monoclonal Antibody (Clone 7F8)
Acetyl Lysine Polyclonal Antibody HRP Conjugate

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