13733 Akt1 (Phospho-Ser473) Monoclonal Antibody (Clone 104A282)
Akt1 (Phospho-Ser473) Monoclonal Antibody (Clone 104A282) Workbook Links
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Antigen:
synthetic peptide from human Akt1 containing phospho-serine473
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Clone designation:
104A282
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Host:
mouse
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Isotype:
IgG2κ
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Application(s):
IP and WB
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Akt, protein kinase B (PKB), is a serine/threonine kinase which is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activate phosphatidylinositol 3-kinase (PI3-kinase). The major activity of Akt/PKB is to mediate cell survival. Akt/PKB is also believed to be a critical factor in the genesis of cancer, as the tumor suppressor PTEN was found to antagonise PI3 kinase and Akt/PKB kinase activity. Akt/PKB phosphorylation is critical for its activity. The major phosphorylation sites required for Akt activation have been identified as threoinine 308 and serine 473. Serine473 is phosphorylated by MAPKAP kinase 2.
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Purchase 13733 Akt1 (Phospho-Ser473) Monoclonal Antibody (Clone 104A282)
Pricing is for North America only. Other customers should contact a distributor in their region.
This product is also available to buy in bulk quantities.
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Sales Department
for a quote or to purchase.
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Warning This product is not for human or veterinary use.
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Pricing updated 2010-03-19.
Prices are subject to change without notice.
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