Cayman Chemical | Akt (Isoforms 1, 2, 3) Inhibitory Peptide Set

13738 Akt (Isoforms 1, 2, 3) Inhibitory Peptide Set

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• See more Inhibitors; Apoptosis; Signal Transduction

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Akt is a protein kinase that plays a central role in inhibiting apoptosis through promoting cell survival. Activated Akt functions by phosphorylating downstream targets in survival signaling pathways. TCL1 (a proto-oncogene underlying human T-cell prolymphocytic leukemia) interacts with Akt through an N-terminal pleckstrin homology (PH) domain and functions as an Akt kinase co-activator. This inhibitory peptide interacts with Akt.¹ The peptide binds to the PH domain of Akt and inhibits Akt1, Akt2, and Akt3 kinase activity. The Akt (Isoforms 1, 2, 3) inhibitory peptide also contains a protein transduction (PTD) sequence (DRQIKIWFQNRRMKWKK) derived from antennapedia which renders the peptide cell permeable.² The control peptide consists of only the PTD sequence.

1 Hiromura, M., Okada, F., Obata, T., et al. Inhibition of Akt kinase activity by a peptide spanning the βA strand of the proto-oncogene TCL1. J Biol Chem 279(51) 53407-53418 (2004).

2 Derossi, D., Joliot, A.H., Chassaing, G., et al. The third helix of the antennapedia homeodomain translocates through biological membranes. J Biol Chem 269(14) 10444-10450 (1994).

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Pricing updated 2010-03-19.
Prices are subject to change without notice.

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