13743 FoxP3Δ2 (exon 2 deleted) Specific Monoclonal Antibody (Clone 16J4G6) (azide free)
FoxP3Δ2 (exon 2 deleted) Specific Monoclonal Antibody (Clone 16J4G6) (azide free) Workbook Links
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Antigen:
synthetic peptide corresponding to the exon 2 deletion sit
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Clone designation:
16J4G6
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Host:
mouse
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Isotype:
IgMκ
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Application(s):
WB
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One of the many immunotolerance mechanisms that the immune system has developed to distinguish between self and non-self antigens are regulatory T-cells or Tregs. Several elegant experiments using transgenic mice and retrovirus-mediated over-expression studies have led to the identification of FoxP3, a transcription factor, as a specific molecular marker essential for the development and function of Tregs. The primary evidence regarding the involvement of FoxP3 in the development of Tregs was provided in patients suffering from IPEX, a rare and fatal human autoimmune disease. The emergence of Tregs and the role of FoxP3 as a critical player in the negative control of various normal and pathological immune responses holds great promise for the development of novel therapies for autoimmune diseases.
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Purchase 13743 FoxP3Δ2 (exon 2 deleted) Specific Monoclonal Antibody (Clone 16J4G6) (azide free)
Pricing is for North America only. Other customers should contact a distributor in their region.
This product is also available to buy in bulk quantities.
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Sales Department
for a quote or to purchase.
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Warning This product is not for human or veterinary use.
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Pricing updated 2010-03-15.
Prices are subject to change without notice.
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