FoxP3Δ2 (exon 2 deleted) Specific Monoclonal Antibody (Clone 16J4G6)
Cayman Chemical Item Number 13744
FoxP3Δ2 (exon 2 deleted) Specific Monoclonal Antibody (Clone 16J4G6)
Description
Antigen:
synthetic peptide corresponding to the exon 2 deletion site
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Clone designation:
16J4G6
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Host:
Mouse
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Isotype:
IgMκ
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Application(s):
WB
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One of the many immunotolerance mechanisms that the immune system has developed to distinguish between self and non-self antigens are regulatory T-cells or Tregs. Several elegant experiments using transgenic mice and retrovirus-mediated over-expression studies have led to the identification of FoxP3, a transcription factor, as a specific molecular marker essential for the development and function of Tregs. The primary evidence regarding the involvement of FoxP3 in the development of Tregs was provided in patients suffering from IPEX, a rare and fatal human autoimmune disease. The emergence of Tregs and the role of FoxP3 as a critical player in the negative control of various normal and pathological immune responses holds great promise for the development of novel therapies for autoimmune diseases.
| Formulation |
100 µg of ammonium sulfate-purified IgG in 200 µl PBS containing 0.05% BSA and 0.05% sodium azid |
| Stability |
1 year |
| Storage |
-20°C |
| Shipping |
Wet ice
in continental US; may vary elsewhere
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| Specificity |
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Pricing updated 2012-02-12.
Prices are subject to change without notice.
To ask for assistance with one of our products please contact a Technical Support Scientist.
Warning This product is not for human or veterinary use.
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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.
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