Antigen: synthetic peptide corresponding to human MyD88 amino acids 233-248 · Host: rabbit · Application(s): WB · MyD88, a protein involved in interleukin-1 (IL-1) mediated signaling, was originally isolated as myeloid differentiation primary response gene.^1,2 MyD88 possesses an N-terminal death domain similar to cytoplasmic segments of TNF receptor 1, Fas, and C-terminal region related to IL-1 and toll receptors. Overexpression of MyD88 induces activation of the c-Jun N-terminal kinase and NF-κB through its death domain.^3,4 The C-terminus of MyD88 interacts with the IL-1 receptor and blocks NF-κB activation induced by IL-1, but not by TNF.

1 Bonnert, T.P., Garka, K.E., Parnet, P., et al. The cloning and characterization of human MyD88: A member of an IL-1 receptor related family. FEBS Lett 402(1) 81-84 (1997).

2 Hardiman, G., Rock, F.L., Balsubramanian, S., et al. Molecular characterization and modular analysis of human MyD88. Oncogene 13(11) 2467-2475 (1997).

3 Burns, K., Martinon, F., Esslinger, C., et al. MyD88, an adapter protein involved in interleukin-1 signaling. J Biol Chem 273(20) 12203-12209 (1998).

4 Wesche, H., Henzel, W.J., Shillinglaw, W., et al. MyD88: An adapter that recuits IRAK to the IL-1 receptor complex. Immunity 7(6) 837-847 (1997).

Hardiman, G., Rock, F.L., Balsubramanian, S., et al. Molecular characterization and modular analysis of human MyD88. Oncogene 13(11) 2467-2475 (1997).

Wesche, H., Henzel, W.J., Shillinglaw, W., et al. MyD88: An adapter that recuits IRAK to the IL-1 receptor complex. Immunity 7(6) 837-847 (1997).

Burns, K., Martinon, F., Esslinger, C., et al. MyD88, an adapter protein involved in interleukin-1 signaling. J Biol Chem 273(20) 12203-12209 (1998).

Bonnert, T.P., Garka, K.E., Parnet, P., et al. The cloning and characterization of human MyD88: A member of an IL-1 receptor related family. FEBS Lett 402(1) 81-84 (1997).

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