13748  MyD88 Homodimerization Inhibitory Peptide Set
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Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

MyD88 is an adapter protein that links toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs) with downstream signaling molecules. Homodimerization of MyD88 is a critical step in the signaling process and allows the recruitment and activation of the kinase IRAK. MyD88 exists as a homodimer when recruited to activate TLR/IL-receptors (TIR). The inhibitor peptide contains a sequence from the MyD88 TIR homodimerization domain.1 MyD88 monomer binds to this inhibitor peptide, thereby blocking Myd88 homodimerization. The MyD88 homodimerization inhibitory peptide contains a protein transduction (PTD) sequence (DRQIKIWFQNRRMKWKK) derived from antennapedia which renders the peptide cell permeable.2 The control peptide consists of only the PTD sequence.
1  Loiarro, M., Sette, C., Gallo, G., et al. Peptide-mediated interference of TIR domain dimerization in MyD88 inhibits interleukin-1-dependent activation of NF-kB. J Biol Chem 280(16) 15809-15814 (2005).
2  Derossi, D., Joliot, A.H., Chassaing, G., et al. The third helix of the antennapedia homeodomain translocates through biological membranes. J Biol Chem 269(14) 10444-10450 (1994).


Purchase 13748 MyD88 Homodimerization Inhibitory Peptide Set

Pricing is for North America only. Other customers should contact a distributor in their region.

This product is also available to buy in bulk quantities. Please contact our Sales Department for a quote or to purchase.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact our Technical Help staff.

Warning This product is not for human or veterinary use.

Pricing updated 2010-03-18.
Prices are subject to change without notice.

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