Antigen: synthetic peptides corresponding to human ANP32A amino acids 87-103 and 231-246 · Host: Rabbit · Application(s): WB · Acidic leucine-rich nuclear phosphoprotein 32 family member A (ANP32A) has been implicated in a nuclear number of cellular processes. These include proliferation, differentiation, caspase-dependent, and -independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability, and inhibition of acetyltransferases as part of the inhibitor of histone acetyltransferases (INHAT) complex.^1,2,3 It also plays a role in E4F1-mediated transcriptional repression.⁴

1 Tsujio, I., Zaidi, T., Xu, J., et al. Inhibitors of protein phosphatase-2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau. FEBS Lett 579 363-372 (2005).

2 Brody, J.R., Kadkol, S.S., Mahmoud, M.A., et al. Identification of sequences required for inhibition of oncogene-mediated transformation by pp32. J Biol Chem 274(29) 20053-20055 (1999).

3 Bai, J., Brody, J.R., Kadkol, S.S., et al. Tumor suppression and potentiation by manipulation of pp32 expression. Oncogene 20 2153-2160 (2001).

4 Cvetanovic, M., Rooney, R.J., Garcia, J.J., et al. The role of LANP and ataxin 1 in E4F-mediated transcriptional repression. EMBO Rep 8(7) 671-677 (2007).

Cvetanovic, M., Rooney, R.J., Garcia, J.J., et al. The role of LANP and ataxin 1 in E4F-mediated transcriptional repression. EMBO Rep 8(7) 671-677 (2007).

Bai, J., Brody, J.R., Kadkol, S.S., et al. Tumor suppression and potentiation by manipulation of pp32 expression. Oncogene 20 2153-2160 (2001).

Tsujio, I., Zaidi, T., Xu, J., et al. Inhibitors of protein phosphatase-2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau. FEBS Lett 579 363-372 (2005).

Brody, J.R., Kadkol, S.S., Mahmoud, M.A., et al. Identification of sequences required for inhibition of oncogene-mediated transformation by pp32. J Biol Chem 274(29) 20053-20055 (1999).

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