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Limaprost

Cayman Chemical Item Number 13810

17α,20-dimethyl-Δ²-Prostaglandin E₁; 17α,20-dimethyl-Δ²-PGE₁ (CAS 74397-12-9)

Limaprost (CAS 74397-12-9)

See more	Inhibitors (493) Prostaglandins (513) Cardiology (79)

Description

Limaprost is an analog of PGE₁ with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is orally active in both rats and guinea pigs at doses of 100 µg/kg as an inhibitor of ADP and collagen induced platelet aggregation. Limaprost is 10-1,000 times more potent than PGE₁ as an inhibitor of platelet adhesiveness measured in vitro. Intra-coronary injection (100 ng/kg) or intravenous injection (3 µg/kg) in anesthetized dogs causes vasodilation and increased coronary blood flow by 60-80%. Significant hypotensive effects were seen at 100 and 300 µg/kg orally in rats.¹

1 Tsuboi, T., Hatano, N., Nakatsuji, K., et al. Pharmacological evaluation of OP 1206, a prostaglandin E₁ derivative, as an antianginal agent. Arch Int Pharmacodyn 247 89-102 (1980).

Synonyms	17α,20-dimethyl-Δ2-Prostaglandin E1 17α,20-dimethyl-Δ2-PGE1
Formal Name	11α,15S-dihydroxy-17S,20-dimethyl-9-oxo-prosta-2E,13E-dien-1-oic acid
CAS Number	74397-12-9
Molecular Formula	C₂₂H₃₆O₅
Formula Weight	380.5
Formulation	A crystalline solid
Purity	>98%
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O[C@H]1[C@H](/C=C/[C@@H](O)C[C@@H](C)CCCC)[C@@H](CCCC/C=C/C(O)=O)C(C1)=O

Background Reading

Tsuboi, T., Hatano, N., Nakatsuji, K., et al. Pharmacological evaluation of OP 1206, a prostaglandin E₁ derivative, as an antianginal agent. Arch Int Pharmacodyn 247 89-102 (1980).

Limaprost is available in the following screening libraries:

Size	Price	Quantity	Subtotal
1 mg	$54.00		$0.00
5 mg	$243.00		$0.00
10 mg	$432.00		$0.00
50 mg	$1,890.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

3-methoxy Limaprost

Prostaglandin E₁

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