Cayman Chemical | Misoprostol (free acid) | Description (CAS 112137-89-0)

13821 Misoprostol (free acid)

(CAS 112137-89-0)

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Misoprostol is a PGE₁ analog with agonist activity mediated by EP₂, EP₃, and EP₄ receptors.^1,2,3,4 It has been shown to inhibit the formation of gastric lesions in rats (ED₅₀ = 0.31 µg/kg),² inhibit superoxide generation in human neutrophils (EC₅₀ = 0.35 µM),³ and relax fetal rabbit ductus arteriosus (EC₅₀ = 0.36 nM)⁴ in a concentration dependent manner. Misoprostol is commonly used in clinical medicine for the prevention of peptic ulcer disease. It has also been used in conjunction with RU-486 for the oral induction of first trimester abortion. Misoprostol contains a C-1 methyl ester and is readily absorbed and rapidly hydrolyzed in humans to the active free acid.¹

1 Walt, R.P. Misoprostol for the treatment of peptic ulcer and antiinflammatory-drug-induced gastroduodenal ulceration. N Engl J Med 327 1575-1580 (1992).

2 Bunce, K.T., Clayton, N.M., Coleman, R.A., et al. GR63799X - a novel prostanoid with selectivity for EP₃ receptors. Adv Prostaglandin Thromboxane Leukot Res 21 379-382 (1990).

3 Talpain, E., Armstrong, R.A., Coleman, R.A., et al. Characterization of the PGE receptor subtype mediating inhibition of superoxide production in human neutrophils. Br J Pharmacol 114 1459-1465 (1995).

4 Smith, G.C.S., Coleman, R.A., McGrath, J.C. Characterization of dilator prostanoid receptors in the fetal rabbit ductus arteriosus. J Pharmacol Exp Ther 271 390-396 (1994).

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Pricing updated 2010-03-14.
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Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.