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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

JWH 018-d9 (solution)

Cayman Chemical Item Number 13824

JWH 018-d9 (solution)

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Description

JWH 018-d9 contains nine deuterium atoms at the 2, 2’, 3, 3’, 4, 4’, 5, 5, and 5 positions. It is intended for use as an internal standard for the quantification of JWH 018 by GC- or LC-mass spectrometry (MS). JWH 018 is a mildly selective agonist of the peripheral cannabinoid (CB2) receptor, derived from the aminoalkylindole WIN 55212-2. The Ki values for binding to the central cannabinoid (CB1) and CB2 receptors are 9.0 and 2.94 nM, respectively, for a CB1:CB2 ratio of 3.06.1 Its effects on suppression of spontaneous activity, maximum possible antinociceptive effect in the tail-flick assay, and rectal temperature are comparable to those of WIN 55212-2 when tested in rats.2

1 Aung, M.M., Griffin, G., Huffman, J.W., et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding. Drug Alcohol Depend 60 133-140 (2000).

2 Wiley, J.L., Compton, D.R., Dai, D., et al. Structure-activity relationships of indole- and pyrrole-derived cannabinoids. J Pharmacol Exp Ther 285(3) 995-1004 (1998).

Formal Name (1-​pentyl-​1H-​indol-​3-​yl)-​1-​naphthalenyl-​2,​2,​3,​3,​4,​4,​5,​5,​5-​d9-​methanone
Molecular Formula C24H14D9NO
Formula Weight 350.5
Formulation A solution in methanol
Purity ≥99% deuterated product
λmax 218, 246, 315 nm
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCCn1cc(C(=O)​c2cccc3ccccc23)​c2ccccc12

Background Reading

Aung, M.M., Griffin, G., Huffman, J.W., et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding. Drug Alcohol Depend 60 133-140 (2000).

Wiley, J.L., Compton, D.R., Dai, D., et al. Structure-activity relationships of indole- and pyrrole-derived cannabinoids. J Pharmacol Exp Ther 285(3) 995-1004 (1998).
Size Price Quantity Subtotal
500 µg $75.00 $0.00
1 mg $143.00 $0.00
5 mg $572.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-11. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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JWH 018 2-hydroxyindole metabolite Exclusive
JWH 018 2-hydroxyindole metabolite-d9 Exclusive
JWH 018 2'-naphthyl-N-(1,1-dimethylpropyl) isomer New
JWH 018 2'-naphthyl-N-(1-methylbutyl) isomer
JWH 018 2'-naphthyl-N-(2,2-dimethylpropyl) isomer
JWH 018 2'-naphthyl-N-(2-methylbutyl) isomer Exclusive
JWH 018 4-hydroxyindole metabolite Exclusive
JWH 018 4-hydroxyindole metabolite-d9 Exclusive
JWH 018 5-hydroxyindole metabolite Exclusive
JWH 018 5-hydroxyindole metabolite-d9 Exclusive
JWH 018 6-hydroxyindole metabolite Exclusive
JWH 018 6-hydroxyindole metabolite-d9 Exclusive
JWH 018 6-methoxyindole analog Exclusive
JWH 018 7-hydroxyindole metabolite Exclusive
JWH 018 7-hydroxyindole metabolite-d9 Exclusive
JWH 018 N-(1-methylbutyl) isomer Exclusive
JWH 018 N-(2,2-dimethylpropyl) isomer
(±)-JWH 018 N-(2-hydroxypentyl) metabolite New
JWH 018 N-(4,5-epoxypentyl) analog New
(−)-JWH 018 N-(4-hydroxypentyl) metabolite New
(+)-JWH 018 N-(4-hydroxypentyl) metabolite New
(±)-JWH 018 N-(4-hydroxypentyl) metabolite Exclusive
JWH 018 N-(5-bromopentyl) analog New
JWH 018 N-(5-chloropentyl) analog New
JWH 018 N-(5-hydroxypentyl) metabolite Exclusive
JWH 018 N-(5-hydroxypentyl) β-D-Glucuronide New Exclusive
JWH 018 N-pentanoic acid metabolite Exclusive
JWH 018 (solution)
JWH 019
JWH 073-d7 (solution) Exclusive
JWH 073 N-butanoic acid metabolite-d5 Exclusive
JWH 073 (solution)
JWH 081
JWH 122
JWH 122 N-(5-hydroxypentyl) metabolite Exclusive
JWH 145 New Exclusive
JWH 182 New Exclusive
JWH 200-d5 (solution)
JWH 200 (solution)
JWH 210
JWH 249 New
JWH 250
JWH 250-d5 Exclusive
JWH 251
JWH 370 New
(R)-AM1241 Exclusive
RCS-4
RCS-4-C4 homolog Exclusive
RCS-8 Exclusive
(S)-AM1241 Exclusive
(+)WIN 55212-2 (mesylate)
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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

This product is a DEA exempt preparation of a scheduled compound - no special processing required. For larger quantities or alternate sizes, please contact sales.

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