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11β-Misoprostol

Cayman Chemical Item Number 13825

(CAS 58717-36-5)

11β-Misoprostol (CAS 58717-36-5)

See more	Prostaglandins (517)

Description

Misoprostol is a widely sold analog of prostaglandin E₁ (PGE₁) which has potent but relatively non-selective agonist activity with respect to the prostanoid EP receptor subgroup.¹ Misoprostol has been used therapeutically for many years in humans for the treatment of gastric ulcer disease under the Searle tradename Cytotec.² 11β-Misoprostol is one of several impurities which are possible in the production of commercial lots of bulk misoprostol, and is somewhat difficult to distinguish from other impurities such as 8-iso misoprostol. The pharmacology and EP receptor binding affinity for 11β-misoprostol have not been published.

1 Abramovitz, M., Adam, M., Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta 1483 285-293 (2000).

2 Collins, P.W. Misoprostol: Discovery, development, and clinical applications. Med Res Rev 10 149-172 (1990).

Formal Name	9-oxo-11β,16-dihydroxy-16-methyl-prost-13E-en-1-oic acid, methyl ester
CAS Number	58717-36-5
Molecular Formula	C₂₂H₃₈O₅
Formula Weight	382.5
Formulation	A solution in methyl acetate
Purity	>98%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCC(O)(C)C/C=C/[C@H]([C@H]1CCCCCCC(OC)=O)[C@@H](O)CC1=O

Background Reading

Collins, P.W. Misoprostol: Discovery, development, and clinical applications. Med Res Rev 10 149-172 (1990).

Abramovitz, M., Adam, M., Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta 1483 285-293 (2000).

11β-Misoprostol is available in the following screening library:

Bio-active Lipid II Screening Library (96-Well)

Size	Price	Quantity	Subtotal
500 µg	$143.00		$0.00
1 mg	$272.00		$0.00
5 mg	$1,144.00		$0.00
10 mg	$2,002.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

11β-Prostaglandin E₂ Exclusive

8-iso Misoprostol Exclusive

Misoprostol

Misoprostol (free acid)

Misoprostol (free acid)-d₅

Show all 5 Hide all but first 3

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